As usual, a great piece. I'm not sure, however, that OAS and ADE remain theoretical only, as you state. Have you seen Subramanian and Kumar 2021, showing that we are seeing in fact higher case rates correlating well with higher vaccination rates, across countries and also across US counties. The latter category is more pronounced it seems than the international comparisons. This is at least prima facie data about ADE already happening. Thoughts? https://pubmed.ncbi.nlm.nih.gov/34591202/